Protein Details: Voltage-gated sodium channel subunit beta-4

Protein ID

ICDB_Pro_1149

Protein Name

Voltage-gated sodium channel subunit beta-4

Gene Name

Scn4b; Gm1471

Organism

Mus musculus (Mouse)

Length

228 amino acids

AlphaFoldDB

AF-Q7M729-F1-model_v4.pdb

Function

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels; but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider; scorpion; wasp and sea anemone venom (By similarity).

Sequence

MSRAGNRGNTQARWLGTGLLGLFLLPMYLSLEVSVGKATTIYAINGSSILLPCTFSSCYGFENLYFKWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKTNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEKVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV

PDB Structures

5AYQ 5XAX

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

cardiac muscle cell

DOI ID

10.1371/journal.pbio.1000112; 10.1523/jneurosci.23-20-07577.2003

RefSeq

NP_001013408.1